WORKSHOP LEUKEMIC AND CANCER STEM CELLS

PROGRAM
I. Signatures of “stem cellness”

* Transcription factor C/EBP alpha regulates hematopoietic stem cell
* proliferation during aging
* Towards the goal of suppressing leukemic stem cell function
* Deregulation of transcriptional network involved in HSC self-renewal
* and early differentiation

II. Malignant stem cells in hematopoietic disease identification and targeting

* Novel targets for eradication of cancer stem cells in CML
* Targeting the survival and engraftment of CML stem cells
* Myeloma stem cells
* Myeloma
* Pre-leukemia

III. Workgroups

* Workgroup on cell culture, amplification and banking
* Workgroup on animal models and engraftment
* Workgroup on immuno-staining, cell sorting and purification

IV. Cancer Stem cell assays (flow, culture, engraftment)

* Flow citometry
* BMI collaborates with BCR-ABL in inducing leukemic transformation of human CD34+ cells in vitro and in vivo
* Utility and pitfall of the xenotransplantation model in the study of leukemic stem cells
* Hematopoietic stem cell niches and leukemia stem cells